Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex

Boundaries in the bithorax complex (BX-C) delimit autonomous regulatory domains that drive parasegment-specific expression of the Hox genes Ubx, abd-A, and Abd-B. The Fab-7 boundary is located between the iab-6 and iab-7 domains and has two key functions: blocking cross-talk between these domains an...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kyrchanova, Olga, Sabirov, Marat, Mogila, Vladic, Kurbidaeva, Amina, Postika, Nikolay, Maksimenko, Oksana, Schedl, Paul, Georgiev, Pavel
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613175/
https://ncbi.nlm.nih.gov/pubmed/31209019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907190116
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