Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence

Cellular senescence is triggered by diverse stimuli and is characterized by long‐term growth arrest and secretion of cytokines and chemokines (termed the SASP—senescence‐associated secretory phenotype). Senescence can be organismally beneficial as it can prevent the propagation of damaged or mutated...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Pantazi, Asimina, Quintanilla, Andrea, Hari, Priya, Tarrats, Nuria, Parasyraki, Eleftheria, Dix, Flora L., Patel, Jaiyogesh, Chandra, Tamir, Acosta, Juan Carlos, Finch, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612703/
https://ncbi.nlm.nih.gov/pubmed/31148378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12981
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