Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence

Cellular senescence is triggered by diverse stimuli and is characterized by long‐term growth arrest and secretion of cytokines and chemokines (termed the SASP—senescence‐associated secretory phenotype). Senescence can be organismally beneficial as it can prevent the propagation of damaged or mutated...

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Publicado en:Aging Cell
Autores principales: Pantazi, Asimina, Quintanilla, Andrea, Hari, Priya, Tarrats, Nuria, Parasyraki, Eleftheria, Dix, Flora L., Patel, Jaiyogesh, Chandra, Tamir, Acosta, Juan Carlos, Finch, Andrew J.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612703/
https://ncbi.nlm.nih.gov/pubmed/31148378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12981
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