α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

α‐Synuclein (aSyn) toxicity is associated with cell cycle alterations, activation of DNA damage responses (DDR), and deregulation of autophagy. However, the relationships between these phenomena remain largely unknown. Here, we demonstrate that in a yeast model of aSyn toxicity and aging, aSyn expre...

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Detaylı Bibliyografya
Yayımlandı:Aging Cell
Asıl Yazarlar: Sampaio‐Marques, Belém, Guedes, Ana, Vasilevskiy, Igor, Gonçalves, Susana, Outeiro, Tiago F., Winderickx, Joris, Burhans, William C., Ludovico, Paula
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612645/
https://ncbi.nlm.nih.gov/pubmed/30977294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12922
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