Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1

Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by mutations in the PKD1 (~85%) or PKD2 (~15%) gene which, respectively, encode polycystin-1 (PC1) and polycystin-2 (PC2). How PC1 regulates cell proliferation and apoptosis has been studied for decades but the underlying mechanis...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Tang, Yan, Shi, Guang, Yang, JungWoo, Zheng, Wang, Tang, Jingfeng, Chen, Xing-Zhen, Yang, Jianzheng, Wang, Zuocheng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612395/
https://ncbi.nlm.nih.gov/pubmed/31341901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/5320747
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