Efficacy of humanized single large doses of caspofungin on the lethality and fungal tissue burden in a deeply neutropenic murine model against Candida albicans and Candida dubliniensis

BACKGROUND: Echinocandins are the first-line therapy for treatment of invasive Candida infections, but the mortality rate remains high, calling for novel strategies. Giving single larger echinocandin doses infrequently is an alternative regimen. Our aim was to test this novel approach in a neutropen...

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Detalhes bibliográficos
Publicado no:Infect Drug Resist
Main Authors: Prépost, Eszter, Tóth, Zoltán, Perlin, David S, Gesztelyi, Rudolf, Kardos, Gábor, Kovács, Renátó, Nagy, Fruzsina, Forgács, Lajos, Majoros, László
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612285/
https://ncbi.nlm.nih.gov/pubmed/31303773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S198764
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