Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness

BACKGROUND: Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to produce oocytes and replenish the primordial follicle pool. The mechanism that re...

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Bibliographic Details
Published in:Stem Cell Res Ther
Main Authors: Jiang, Yu, Zhu, Dantian, Liu, Wenfeng, Qin, Qiushi, Fang, Zhi, Pan, Zezheng
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612207/
https://ncbi.nlm.nih.gov/pubmed/31277696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1299-5
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