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The Pregnancy Pickle: Evolved immune compensation due to pregnancy underlies sex differences in human diseases

We hypothesize that, ancestrally, sex-specific immune modulation evolved to facilitate survival of the pregnant person in the presence of an invasive placenta and an immunologically challenging pregnancy; an idea we term the Pregnancy Compensation Hypothesis. Further, we propose sex differences in i...

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Publicado en:Trends Genet
Main Authors: Natri, Heini, Garcia, Angela R., Buetow, Kenneth H., Trumble, Benjamin C., Wilson, Melissa A.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611699/
https://ncbi.nlm.nih.gov/pubmed/31200807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2019.04.008
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