Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

BACKGROUND: Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (DCM), due to an impaired catabolism of BCAA, and if stimul...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cardiovasc Diabetol
Päätekijät: Uddin, Golam M., Zhang, Liyan, Shah, Saumya, Fukushima, Arata, Wagg, Cory S., Gopal, Keshav, Al Batran, Rami, Pherwani, Simran, Ho, Kim L., Boisvenue, Jamie, Karwi, Qutuba G., Altamimi, Tariq, Wishart, David S., Dyck, Jason R. B., Ussher, John R., Oudit, Gavin Y., Lopaschuk, Gary D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2019
Aiheet:
Original Investigation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610921/
https://ncbi.nlm.nih.gov/pubmed/31277657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-019-0892-3
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