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Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry
The design of artificial enzymes is an emerging field of research. Although progress has been made, the catalytic proficiency of many designed enzymes is low compared to natural enzymes. Nevertheless, recently Hilvert et al. (Nat. Chem. 2017, 9, 50–56) created a series of five artificial retro-aldol...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6610584/ https://ncbi.nlm.nih.gov/pubmed/31199129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04515 |
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