PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts

PARK20, an early onset autosomal recessive parkinsonism is due to mutations in the phosphatidylinositol-phosphatase Synaptojanin 1 (Synj1). We have recently shown that the early endosomal compartments are profoundly altered in PARK20 fibroblasts as well as the endosomal trafficking. Here, we report...

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Détails bibliographiques
Publié dans:Front Neurosci
Auteurs principaux: Amodio, Giuseppina, Moltedo, Ornella, Fasano, Dominga, Zerillo, Lucrezia, Oliveti, Marco, Di Pietro, Paola, Faraonio, Raffaella, Barone, Paolo, Pellecchia, Maria Teresa, De Rosa, Anna, De Michele, Giuseppe, Polishchuk, Elena, Polishchuk, Roman, Bonifati, Vincenzo, Nitsch, Lucio, Pierantoni, Giovanna Maria, Renna, Maurizio, Criscuolo, Chiara, Paladino, Simona, Remondelli, Paolo
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610533/
https://ncbi.nlm.nih.gov/pubmed/31316342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00673
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