Discovery of 4,6‐bis(2‐((E)‐benzylidene)hydrazinyl)pyrimidin‐2‐Amine with Antibiotic Activity

Robenidine (E)‐N′‐((E)‐1‐(4‐chlorophenyl)ethylidene)‐2‐(1‐(4‐chlorophenyl)ethylidene)hydrazine‐1‐carboximidhydrazide displays methicillin‐resistant Staphyoccoccus aureus (MRSA) and vancomycin‐resistant Enterococci (VRE) MICs of 2 μg mL(−1). Herein we describe the structure‐activity relationship deve...

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Bibliographic Details
Published in:ChemistryOpen
Main Authors: Russell, Cecilia C., Stevens, Andrew, Young, Kelly A., Baker, Jennifer R., McCluskey, Siobhann N., Khazandi, Manouchehr, Pi, Hongfei, Ogunniyi, Abiodun, Page, Stephen W., Trott, Darren J., McCluskey, Adam
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610448/
https://ncbi.nlm.nih.gov/pubmed/31312589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800241
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