Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation

5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes. It is well known that 5-LOX activation in innate immunity cells is related to different iron-associated pro-inflammatory disorders, inc...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dufrusine, Beatrice, Di Francesco, Andrea, Oddi, Sergio, Scipioni, Lucia, Angelucci, Clotilde Beatrice, D'Addario, Claudio, Serafini, Mauro, Häfner, Ann-Kathrin, Steinhilber, Dieter, Maccarrone, Mauro, Dainese, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610208/
https://ncbi.nlm.nih.gov/pubmed/31316498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01347
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