Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-κB pathway

Extracellular acidification is a very common cause of stress in tumor microenvironment and of Darwinian pressure. In acid areas of the tumor, most cancer cells are-albeit slowly proliferating-more resistant to cell death than those in well-perfused regions. Tumor acidosis can directly regulate the e...

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Publicat a:Am J Cancer Res
Autors principals: Avnet, Sofia, Chano, Tokuhiro, Massa, Annamaria, Bonuccelli, Gloria, Lemma, Silvia, Falzetti, Luigi, Grisendi, Giulia, Dominici, Massimo, Baldini, Nicola
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610055/
https://ncbi.nlm.nih.gov/pubmed/31285947
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