Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram

Due to its potent anticancer activity, there is interest in repurposing of the FDA-approved anti-alcoholism drug, disulfiram (DSF). DSF forms potent complexes with copper (DSF/Cu) that induce apoptosis of many types of cancer cells. Here, we investigated the role of DSF/Cu in autophagy, a mechanism...

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Pubblicato in:Am J Cancer Res
Autori principali: Zhang, Xiao, Hu, Pan, Ding, Shi-Ying, Sun, Ting, Liu, Ling, Han, Shiwei, DeLeo, Albert B, Sadagopan, Ananthan, Guo, Wei, Wang, Xinhui
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610050/
https://ncbi.nlm.nih.gov/pubmed/31285958
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