Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy

OBJECTIVE: Elevated glycolytic enzymes in renal glomeruli correlated with preservation of renal function in the Medalist Study, individuals with ≥50 years of type 1 diabetes. Specifically, pyruvate kinase M2 (PKM2) activation protected insulin-deficient diabetic mice from hyperglycemia-induced glome...

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Опубликовано в: :Diabetes Care
Главные авторы: Gordin, Daniel, Shah, Hetal, Shinjo, Takanori, St-Louis, Ronald, Qi, Weier, Park, Kyoungmin, Paniagua, Samantha M., Pober, David M., Wu, I-Hsien, Bahnam, Vanessa, Brissett, Megan J., Tinsley, Liane J., Dreyfuss, Jonathan M., Pan, Hui, Dong, Yutong, Niewczas, Monika A., Amenta, Peter, Sadowski, Thorsten, Kannt, Aimo, Keenan, Hillary A., King, George L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2019
Предметы:
Pathophysiology/Complications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609957/
https://ncbi.nlm.nih.gov/pubmed/31076418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc18-2585
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