The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

Infection of host cells by Toxoplasma gondii is an active process, which is regulated by secretion of microneme (MICs) and rhoptry proteins (ROPs and RONs) from specialized organelles in the apical pole of the parasite. MIC1, MIC4 and MIC6 assemble into an adhesin complex secreted on the parasite su...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Sardinha-Silva, Aline, Mendonça-Natividade, Flávia C., Pinzan, Camila F., Lopes, Carla D., Costa, Diego L., Jacot, Damien, Fernandes, Fabricio F., Zorzetto-Fernandes, André L. V., Gay, Nicholas J., Sher, Alan, Jankovic, Dragana, Soldati-Favre, Dominique, Grigg, Michael E., Roque-Barreira, Maria Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608980/
https://ncbi.nlm.nih.gov/pubmed/31226171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007871
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