Reducing Glypican-4 in ES Cells Improves Recovery in a Rat Model of Parkinson's Disease by Increasing the Production of Dopaminergic Neurons and Decreasing Teratoma Formation

The heparan sulfate proteoglycan Glypican 4 (Gpc4) is strongly expressed in mouse embryonic stem (ES) cells where it controls the maintenance of self-renewal by modulating Wnt/β-catenin signaling activities. Here we show that mouse ES cells carrying a hypomorphic Gpc4 allele, in a single-step neuron...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Fico, Annalisa, de Chevigny, Antoine, Melon, Christophe, Bohic, Manon, Kerkerian-Le Goff, Lydia, Maina, Flavio, Dono, Rosanna, Cremer, Harold
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608242/
https://ncbi.nlm.nih.gov/pubmed/24920634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2501-13.2014
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