Defects in CD4(+) T cell LFA‐1 integrin‐dependent adhesion and proliferation protect Cd47 (−/−) mice from EAE

CD47 is known to play an important role in CD4(+) T cell homeostasis. We recently reported a reduction in mice deficient in the Cd47 gene (Cd47(−/−)) CD4(+) T cell adhesion and transendothelial migration (TEM) in vivo and in vitro as a result of impaired expression of high‐affinity forms of LFA‐1 an...

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Dettagli Bibliografici
Pubblicato in:J Leukoc Biol
Autori principali: Azcutia, Veronica, Bassil, Ribal, Herter, Jan M., Engelbertsen, Daniel, Newton, Gail, Autio, Anu, Mayadas, Tanya, Lichtman, Andrew H., Khoury, Samia J., Parkos, Charles A., Elyaman, Wassim, Luscinskas, Francis W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Inflammation, Extracellular Mediators, & Effector Molecules
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608006/
https://ncbi.nlm.nih.gov/pubmed/27965383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1215-546RR
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