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Chaperone-like activity of the N-terminal region of a human small heat shock protein and chaperone-functionalized nanoparticles

Small heat shock proteins (sHsps) are molecular chaperones employed to interact with a diverse range of substrates as the first line of defense against cellular protein aggregation. The N-terminal region (NTR) is implicated in defining features of sHsps; notably in their ability to form dynamic and...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Gliniewicz, Emily F., Chambers, Kelly M., De Leon, Elizabeth R., Sibai, Diana, Campbell, Helen C., McMenimen, Kathryn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607909/
https://ncbi.nlm.nih.gov/pubmed/30684363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25662
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