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RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs

A gene delivery system that allows efficient and safe stem cell modification is critical for next-generation stem cell therapies. An RNA virus-based episomal vector (REVec) is a gene transfer system developed based on Borna disease virus (BoDV), which facilitates persistent intranuclear RNA transgen...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Komatsu, Yumiko, Takeuchi, Dan, Tokunaga, Tomoya, Sakurai, Hidetoshi, Makino, Akiko, Honda, Tomoyuki, Ikeda, Yasuhiro, Tomonaga, Keizo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606997/
https://ncbi.nlm.nih.gov/pubmed/31309127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.05.010
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