Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome

BACKGROUND: Enhanced GABA activity in the brain and a hyperactive hypothalamic-pituitary-gonadal axis are associated with polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility. Women with PCOS exhibit elevated cerebrospinal fluid GABA levels and preclinical models of PCOS...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Silva, Mauro S.B., Desroziers, Elodie, Hessler, Sabine, Prescott, Melanie, Coyle, Chris, Herbison, Allan E., Campbell, Rebecca E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606966/
https://ncbi.nlm.nih.gov/pubmed/31178425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.065
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