DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces

DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the DYT1/TOR1A gene, which encodes torsinA, a conserved luminal ATPases-associated with various cellular activities (AAA+) protein. TorsinA is required for the assembly of functional linker of nucleosk...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Dev Biol
Prif Awduron: Gill, Navjot Kaur, Ly, Chau, Kim, Paul H., Saunders, Cosmo A., Fong, Loren G., Young, Stephen G., Luxton, G. W. Gant, Rowat, Amy C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Cell and Developmental Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606767/
https://ncbi.nlm.nih.gov/pubmed/31294022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00103
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