Structural basis of Q-dependent transcription antitermination

Bacteriophage Q protein engages σ-dependent paused RNA polymerase (RNAP) by binding to a DNA site embedded in late gene promoter and renders RNAP resistant to termination signals. Here, we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact Q-engaged arrested complex....

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Udgivet i:Nat Commun
Main Authors: Shi, Jing, Gao, Xiang, Tian, Tongguan, Yu, Zhaoyang, Gao, Bo, Wen, Aijia, You, Linlin, Chang, Shenghai, Zhang, Xing, Zhang, Yu, Feng, Yu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606751/
https://ncbi.nlm.nih.gov/pubmed/31266960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10958-8
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