TcG2/TcG4 DNA Vaccine Induces Th1 Immunity Against Acute Trypanosoma cruzi Infection: Adjuvant and Antigenic Effects of Heterologous T. rangeli Booster Immunization

Background: Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). Two antigenic candidates, TcG2 and TcG4, are recognized by antibodies in naturally infected dogs and humans; and these vaccine candidates provided protection from Tc infection in mice and dogs. Trypanosoma rangeli (Tr) is non-pat...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Gupta, Shivali, Salgado-Jiménez, Berenice, Lokugamage, Nandadeva, Vázquez-Chagoyán, Juan Carlos, Garg, Nisha Jain
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606718/
https://ncbi.nlm.nih.gov/pubmed/31293599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01456
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