Hypoxia-induced VISTA promotes the suppressive function of myeloid- derived suppressor cells in the tumor microenvironment

Tumor hypoxia is a negative prognostic factor that is implicated in oncogenic signal activation, immune escape, and resistance to treatment. Identifying the mechanistic role of hypoxia in immune escape and resistance to immune checkpoint inhibitors may aid identification of therapeutic targets. We a...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Deng, Jie, Li, Jiannan, Sarde, Aurelien, Lines, J. Louise, Lee, Yu-Chi, Qian, David C., Pechenick, Dov A., Manivanh, Richard, LeMercier, Isabelle, Lowrey, Christopher H., Varn, Frederick S., Cheng, Chao, Leib, David A., Noelle, Randolph J., Mabaera, Rodwell
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606337/
https://ncbi.nlm.nih.gov/pubmed/31088847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0507
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