DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer.

Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (AZA) activates type I interferon signaling to increase IFNγ+ T cells and NK cells and reduce the percentage of macrophages in the tumor mi...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Travers, Meghan, Brown, Stephen M., Dunworth, Matthew, Holbert, Cassandra E., Wiehagen, Karla R., Bachman, Kurtis E., Foley, Jackson R., Stone, Meredith L., Baylin, Stephen B., Casero, Robert A., Zahnow, Cynthia A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606334/
https://ncbi.nlm.nih.gov/pubmed/31088836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-4018
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