Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryoni...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hardy, Holly, Prendergast, James GD, Patel, Aara, Dutta, Sunit, Trejo-Reveles, Violeta, Kroeger, Hannah, Yung, Andrea R, Goodrich, Lisa V, Brooks, Brian, Sowden, Jane C, Rainger, Joe
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606025/
https://ncbi.nlm.nih.gov/pubmed/31162046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43877
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