Mitochondrial ATP-Mg/Pi Carrier SCaMC-3/Slc25a23 Counteracts PARP-1-Dependent Fall in Mitochondrial ATP Caused by Excitotoxic Insults in Neurons

Glutamate excitotoxicity is caused by sustained activation of neuronal NMDA receptors causing a large Ca(2+) and Na(+) influx, activation of poly(ADP ribose) polymerase-1 (PARP-1), and delayed Ca(2+) deregulation. Mitochondria undergo early changes in membrane potential during excitotoxicity, but th...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rueda, Carlos B., Traba, Javier, Amigo, Ignacio, Llorente-Folch, Irene, González-Sánchez, Paloma, Pardo, Beatriz, Esteban, José A., del Arco, Araceli, Satrústegui, Jorgina
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605552/
https://ncbi.nlm.nih.gov/pubmed/25716855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2702-14.2015
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