APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration

Contrary to Alzheimer's disease (AD), the APOE2 allele increases and the APOE4 allele reduces the risk to develop age-related macular degeneration (AMD) compared with the most common APOE3 allele. The underlying mechanism for this association with AMD and the reason for the puzzling difference...

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Udgivet i:J Neurosci
Main Authors: Levy, Olivier, Lavalette, Sophie, Hu, Shulong J., Housset, Michael, Raoul, William, Eandi, Chiara, Sahel, José-Alain, Sullivan, Patrick M., Guillonneau, Xavier, Sennlaub, Florian
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605380/
https://ncbi.nlm.nih.gov/pubmed/26446211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2468-15.2015
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