Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Loss of vision in glaucoma results from the selective death of retinal ganglion cells (RGCs). Tumor necrosis factor α (TNFα) signaling has been linked to RGC damage, however, the mechanism by which TNFα promotes neuronal death remains poorly defined. Using an in vivo rat glaucoma model, we show that...

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Udgivet i:J Neurosci
Main Authors: Cueva Vargas, Jorge L., Osswald, Ingrid K., Unsain, Nicolas, Aurousseau, Mark R., Barker, Philip A., Bowie, Derek, Di Polo, Adriana
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605307/
https://ncbi.nlm.nih.gov/pubmed/26338321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1273-15.2015
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