Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration

Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1-deficient mice develop age- and stress- related subretinal accumulation of MPs, which is associated w...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Hu, Shulong J., Calippe, Bertrand, Lavalette, Sophie, Roubeix, Christophe, Montassar, Fadoua, Housset, Michael, Levy, Olivier, Delarasse, Cecile, Paques, Michel, Sahel, José-Alain, Sennlaub, Florian, Guillonneau, Xavier
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605270/
https://ncbi.nlm.nih.gov/pubmed/25948251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3955-14.2015
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