Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Neuritic plaques, a pathological hallmark in Alzheimer’s disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating neurites that accumulate autolysosomes. We found that, in the brains of patients with AD and in AD mouse models, Aβ plaque-associated Olig2- a...

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Bibliografske podrobnosti
izdano v:Nat Neurosci
Main Authors: Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, loannis, Gottimukkala, Kamalvishnu, Cutler, Roy G., Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A., Sen, Jyoti Misra, Gorospe, Myriam, Mattson, Mark P.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605052/
https://ncbi.nlm.nih.gov/pubmed/30936558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0372-9
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