Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators

IMPORTANCE: There is a need for better arrhythmic risk stratification in nonischemic dilated cardiomyopathy (DCM). Titin-truncating variants (TTNtvs) in the TTN gene are the most common genetic cause of DCM and may be associated with higher risk of arrhythmias in patients with DCM. OBJECTIVE: To det...

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Pubblicato in:JAMA Netw Open
Autori principali: Corden, Ben, Jarman, Julian, Whiffin, Nicola, Tayal, Upasana, Buchan, Rachel, Sehmi, Joban, Harper, Andrew, Midwinter, William, Lascelles, Karen, Markides, Vias, Mason, Mark, Baksi, John, Pantazis, Antonis, Pennell, Dudley J., Barton, Paul J., Prasad, Sanjay K., Wong, Tom, Cook, Stuart A., Ware, James S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2019
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604081/
https://ncbi.nlm.nih.gov/pubmed/31251381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.6520
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