Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress

SLC4A11 is a NH(3) sensitive membrane transporter with H(+) channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of SLC4A11 activity induces oxidative stress and cell death, resulting in Congenital Hereditary Endothelial Dystrophy (CHED) wit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Redox Biol
Prif Awduron: Ogando, Diego G., Choi, Moonjung, Shyam, Rajalekshmy, Li, Shimin, Bonanno, Joseph A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604051/
https://ncbi.nlm.nih.gov/pubmed/31254733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101260
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