R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling

BACKGROUND: R-spondins (Rspo) and leucine-rich repeat-containing G-protein-coupled receptors (LGR) play important roles in development, stem cells survival, and tumorigenicity by activating Wnt signaling pathway. Whether R-spondins-LGR signaling affects the progression of squamous cell carcinoma (SC...

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Bibliografische gegevens
Gepubliceerd in:EBioMedicine
Hoofdauteurs: Zhang, Liping, Song, Yan, Ling, Zihang, Li, Yuanyuan, Ren, Xianyue, Yang, Jing, Wang, Zhi, Xia, Juan, Zhang, Weizhen, Cheng, Bin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Research paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6603804/
https://ncbi.nlm.nih.gov/pubmed/31097406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.076
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