Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model

INTRODUCTION: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways. Therefore, we investigated whether the combinati...

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發表在:Front Cell Neurosci
Main Authors: Wowro, Sylvia J., Tong, Giang, Krech, Jana, Rolfs, Nele, Berger, Felix, Schmitt, Katharina R. L.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6603137/
https://ncbi.nlm.nih.gov/pubmed/31293389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00273
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