Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse

In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA). Here, we sought to uncover elusive mechanisms regulating a key...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Velte, Ellen K., Niedenberger, Bryan A., Serra, Nicholas D., Singh, Anukriti, Roa-DeLaCruz, Lorena, Hermann, Brian P., Geyer, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Stem Cells and Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602341/
https://ncbi.nlm.nih.gov/pubmed/31023878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.173088
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