Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration

HIV-1 infection of the brain causes the neurodegenerative syndrome HIV-associated neurocognitive disorders (HAND), for which there is no specific treatment. Herein, we investigated the actions of insulin using ex vivo and in vivo models of HAND. Increased neuroinflammatory gene expression was observ...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Mamik, Manmeet K., Asahchop, Eugene L., Chan, Wing F., Zhu, Yu, Branton, William G., McKenzie, Brienne A., Cohen, Eric A., Power, Christopher
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601935/
https://ncbi.nlm.nih.gov/pubmed/27733618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1287-16.2016
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