Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice

Recombinant human soluble thrombomodulin alpha (rhTM) has been developed as an anticoagulant with anti-inflammatory activity. Notably, acetaminophen (APAP) -induced liver disease (AILI) is caused by direct metabolite-induced hepatotoxicity as well as hepatic hyper-coagulation. To evaluate the utilit...

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Vydáno v:Exp Ther Med
Hlavní autoři: Kuwano, Akifumi, Kohjima, Motoyuki, Suzuki, Hideo, Yamasaki, Akihiro, Ohashi, Tomoko, Imoto, Koji, Kurokawa, Miho, Morita, Yusuke, Kato, Masaki, Ogawa, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601374/
https://ncbi.nlm.nih.gov/pubmed/31316624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2019.7665
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