Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by integrin α(2)β(1). Protein tyrosine kinase Syk is central in the GPVI-induce...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Jooss, Natalie J., De Simone, Ilaria, Provenzale, Isabella, Fernández, Delia I., Brouns, Sanne L.N., Farndale, Richard W., Henskens, Yvonne M.C., Kuijpers, Marijke J.E., ten Cate, Hugo, van der Meijden, Paola E.J., Cavill, Rachel, Heemskerk, Johan W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600290/
https://ncbi.nlm.nih.gov/pubmed/31181592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20112788
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