Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by integrin α(2)β(1). Protein tyrosine kinase Syk is central in the GPVI-induce...

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Publicat a:Int J Mol Sci
Autors principals: Jooss, Natalie J., De Simone, Ilaria, Provenzale, Isabella, Fernández, Delia I., Brouns, Sanne L.N., Farndale, Richard W., Henskens, Yvonne M.C., Kuijpers, Marijke J.E., ten Cate, Hugo, van der Meijden, Paola E.J., Cavill, Rachel, Heemskerk, Johan W.M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600290/
https://ncbi.nlm.nih.gov/pubmed/31181592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20112788
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