Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

Ionizing radiation (IR) has been widely used in the treatment of cancer. Radiation-induced DNA damage triggers the DNA damage response (DDR), which can confer radioresistance and early local recurrence by activating DNA repair pathways. Since karyopherin-α2 (KPNA2), playing an important role in nucl...

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Pubblicato in:Int J Mol Sci
Autori principali: Song, Kyung-Hee, Jung, Seung-Youn, Park, Jeong-In, Ahn, Jiyeon, Park, Jong Kuk, Um, Hong-Duck, Park, In-Chul, Hwang, Sang-Gu, Ha, Hunjoo, Song, Jie-Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600173/
https://ncbi.nlm.nih.gov/pubmed/31212646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20112843
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