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4-Oxoproline as a Site-Specific Infrared Probe: Application to Assess Proline Isomerization and Dimer Formation

Due to its unique structure, proline plays important structural and functional roles in proteins. However, this special amino acid lacks an adequate vibrational mode that can be exploited to probe its local electrostatic and hydration status via infrared spectroscopy. Herein, we show that the C=O st...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Abaskharon, Rachel M., Mukherjee, Debopreeti, Gai, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599745/
https://ncbi.nlm.nih.gov/pubmed/31135160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b03766
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