Assessment of metabolic changes in Mycobacterium smegmatis wild type and alr mutant strains: evidence for a new pathway of D-alanine biosynthesis.

In mycobacteria, D-alanine is an essential precursor for peptidoglycan biosynthesis. The only confirmed enzymatic pathway to form D-alanine is through the racemization of L-alanine by alanine racemase (Alr, EC 5.1.1.1). Nevertheless, the essentiality of Alr in Mycobacterium tuberculosis and Mycobact...

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Pubblicato in:J Proteome Res
Autori principali: Marshall, Darrell D., Halouska, Steven, Zinniel, Denise K., Fenton, Robert J., Kenealy, Katie, Chahal, Harpreet K., Rathnaiah, Govardhan, Barletta, Raúl G., Powers, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599645/
https://ncbi.nlm.nih.gov/pubmed/28121156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00871
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