TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1...

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Vydáno v:Nat Commun
Hlavní autoři: Zhu, Rongxuan, Gires, Olivier, Zhu, Liqun, Liu, Jun, Li, Junjian, Yang, Hao, Ju, Gaoda, Huang, Jing, Ge, Weiyu, Chen, Yi, Lu, Zhimin, Wang, Hongxia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599078/
https://ncbi.nlm.nih.gov/pubmed/31253779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10739-3
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