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Cell population heterogeneity driven by stochastic partition and growth optimality

A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimodality can emerge even when biological processes are homogenous at the cell level and the environment is kept constant. O...

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Publicado en:Sci Rep
Autores principales: Fernandez-de-Cossio-Diaz, Jorge, Mulet, Roberto, Vazquez, Alexei
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599024/
https://ncbi.nlm.nih.gov/pubmed/31253860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45882-w
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