Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Ni, Yingjia, Schmidt, Keon R., Werner, Barnes A., Koenig, Jenna K., Guldner, Ian H., Schnepp, Patricia M., Tan, Xuejuan, Jiang, Lan, Host, Misha, Sun, Longhua, Howe, Erin N., Wu, Junmin, Littlepage, Laurie E., Nakshatri, Harikrishna, Zhang, Siyuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599020/
https://ncbi.nlm.nih.gov/pubmed/31253784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10743-7
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