Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy

Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. Wh...

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Udgivet i:Nano Lett
Main Authors: Sayour, Elias J., Grippin, Adam, Leon, Gabriel De, Stover, Brian, Rahman, Maryam, Karachi, Aida, Wummer, Brandon, Moore, Ginger, Castillo-Caro, Paul, Fredenburg, Kristianna, Sarkisian, Matthew R., Huang, Jianping, Deleyrolle, Loic P., Sahay, Bikash, Carrera-Justiz, Sheila, Mendez-Gomez, Hector R., Mitchell, Duane A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597257/
https://ncbi.nlm.nih.gov/pubmed/30259750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.8b02179
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