Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that:...

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Vydáno v:eLife
Hlavní autoři: Landegren, Nils, Rosen, Lindsey B, Freyhult, Eva, Eriksson, Daniel, Fall, Tove, Smith, Gustav, Ferre, Elise M N, Brodin, Petter, Sharon, Donald, Snyder, Michael, Lionakis, Michail, Anderson, Mark, Kämpe, Olle
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597240/
https://ncbi.nlm.nih.gov/pubmed/31244471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43578
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