Lower Affinity of Isradipine for L-Type Ca(2+) Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease

Ca(2+)-influx through L-type Ca(2+)-channels (LTCCs) is associated with activity-related stressful oscillations of Ca(2+) levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Parkinson's disease (PD). LTCC blockers were ne...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Ortner, Nadine J., Bock, Gabriella, Dougalis, Antonios, Kharitonova, Maria, Duda, Johanna, Hess, Simon, Tuluc, Petronel, Pomberger, Thomas, Stefanova, Nadia, Pitterl, Florian, Ciossek, Thomas, Oberacher, Herbert, Draheim, Henning J., Kloppenburg, Peter, Liss, Birgit, Striessnig, Jörg
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596555/
https://ncbi.nlm.nih.gov/pubmed/28592699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2946-16.2017
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