Coadministration of the prostaglandin F2α receptor antagonist preterm labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone

AIMS: To investigate presence or absence of clinically relevant drug interactions (pharmacokinetic and safety/tolerability) of OBE022 with standard‐of‐care medicines for preterm labour, enabling coadministration and further clinical development. METHODS: Part A: open‐label, randomized, 3‐period cros...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Pohl, Oliver, Marchand, Line, Gotteland, Jean‐Pierre, Coates, Simon, Täubel, Jörg, Lorch, Ulrike
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595366/
https://ncbi.nlm.nih.gov/pubmed/30891820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13925
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